Inturned Planar Cell Polarity Effector Homolog (INTU)

Xint, the frog homolog of INTU, was expressed in the neural plate during neural tube closure, with subsequent strong expression in the ventral neural tube and in facial mesenchyme.

The deduced 953-amino acid protein contains a PDZ domain. RT-PCR ELISA detected highest expression in kidney, ovary, and fetal brain, intermediate expression in heart, adult brain, liver, lung, and skeletal muscle, and little to no expression in pancreas, spleen, and fetal liver. INTU was expressed in all specific adult brain regions examined with highest levels in amygdala, corpus callosum, caudate nucleus, substantia nigra, subthalamic nucleus, and spinal cord.