Janus Kinase And Microtubule Interacting Protein 3 (JAKMIP3)

NECC2 encodes a deduced 844-amino acid protein containing 8 predicted coiled-coil domains, which span most of the sequence, and a 19-amino acid C-terminal transmembrane domain. Like NECC1, NECC2 localizes to the distal compartments of the Golgi complex. both NECC1 and NECC2 were expressed at highest levels in the central nervous system and in endocrine tissues, including pituitary gland, adrenal gland, and testis. Low expression was found in other tissues such as heart, kidney, thymus, and skeletal muscle.

Based on the structure, expression pattern, and sublocalization of the NECC1 and NECC2 proteins, they are members of the golgin family of proteins and may be responsible for Golgi structure or function