Jerky Homolog Like Protein (JRKL)

Toth et al. (1995) found that inactivation of the mouse 'jerky' gene results in epileptic seizures. See 603210. Zeng et al. (1997) identified a human tonsil cDNA encoding a protein similar to jerky. They designated the predicted 442-amino acid protein HHMJG (human homolog of mouse jerky gene).

The HHMJG and mouse jerky proteins are 35% identical. Northern blot analysis revealed that HHMJG is abundantly expressed as a 4-kb mRNA in various tissues. In testis, an additional 2-kb transcript is present. By fluorescence in situ hybridization, Zeng et al. (1997) mapped the HHMJG gene to 11q21.