KIF1 Binding Protein (KBP)

KBP encodes a 621-amino acid protein that shares 89% sequence homology with the mouse homolog. The predicted protein contains 2 tetratricopeptide repeats (TPR). Northern blot analysis of adult and fetal tissues detected expression of a 2.4-kb transcript in all tissues except blood leukocytes. The transcript was present in different parts of the adult central nervous system, including cerebellum, cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe, and putamen.

The deduced protein contains 632 amino acids. RT-PCR detected high expression in heart, brain, ovary, testis, spinal cord, and all specific brain regions examined. Moderate expression was detected in all other adult tissues examined, as well as in fetal liver and brain.