Kelch Like Protein 24 (KLHL24)

KLHL24 contains a BTB/POZ domain near the N-terminus followed by a BACK domain and 6 consecutive kelch repeats. The BTB/POZ domain is a zinc finger and protein-protein dimerization domain. The BACK domain is similar to substrate-specific adaptors for protein ubiquitination, and the 6 kelch repeats likely form a beta-propeller structure. In situ hybridization and immunohistochemistry experiments showed that KLHL24 is widely expressed in rat brain, particularly in the cortex and hippocampus where expression of GluR6 is also prominent.Coexpression of KLHL24 and GluR6 changed currents observed in patch-clamp experiments, suggesting that binding of KLHL24 to GluR6 alters channel operation. Overexpression of KLHL24 reduced endogenous kainate receptor-mediated responses evoked in hippocampal neurons.