Kelch Like Protein 31 (KLHL31)

The deduced human KLHL31 protein contains 634 amino acids, with a kelch repeat domain in the C terminus and a BTB/POX domain in the N terminus. The human and zebrafish proteins share approximately 72% sequence identity. Northern blot analysis of human tissues detected a single 6-kb KLHL31 transcript with strong expression in skeletal muscle and weak expression in heart, consistent with the expression pattern in zebrafish.By sequence analysis, Wu and Gong (2004) mapped the zebrafish klhl gene to linkage group (LG) 13, and the human KLHL31 gene to a region of syntenic homology on chromosome 6p12. They also mapped the mouse and rat klhl orthologs to regions of syntenic homology on chromosome 9 and chromosome 8, respectively.