Kelch Like Protein 5 (KLHL5)

Wang et al. (2001) cloned a full-length KLHL5 cDNA from a human fetal brain cDNA library. The cDNA encodes a deduced 755-amino acid protein that contains a BTB/POZ domain at the N terminus and 6 tandemly arranged kelch repeats (kelch domain) at the C terminus. Both the BTB and kelch domains are conserved in members of the kelch protein family. KLHL5 shares 43% sequence identity with the Drosophila Kelch protein, an oligomeric ring canal actin organizer. It also shares significant sequence identity with human KLHL2 and KLHL3. Northern blot analysis revealed a single KLHL5 band with high expression in ovary, adrenal gland, and thyroid, lower expression in prostate, testis, spinal cord, lymph node, and trachea, and no expression in any other tissue examined.