Kelch Repeat And BTB Domain Containing Protein 2 (KBTBD2)

The N-terminus of several Kelch proteins contain other protein domains, including Discoidin, F-box, and Broad-complex, Tramtrack, Bric-a-Brac/Poxvirus and Zincfinger (BTB/POZ) domains. Kelch proteins may also have only a β-propeller architecture only. The BTB domain of kelch proteins (if present) allows the formation of homo- or heterodimers that mediate protein-protein interactions.

The level of Kbtbd2 mRNA was higher in subcutaneous adipose tissue than in visceral adipose tissue in cattle . In contrast, in both pigs and in mice fed the control diet, Kbtbd2 expression was higher in visceral adipose tissue than in subcutaneous adipose tissue. The levels of Kbtdb2 were elevated significantly in subcutaneous adipose tissue in mice fed the high-fat diet.