Keratin 34 (KRT34)

KRT34 is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.One hair keratin, which they named HA4, had a molecular mass of 43 kD and an isoelectric point of 4.8.KRTHA4 is expressed in the human hair follicle.

The functional hair keratins and hypothetical HAA hair keratin share approximately 81% overall amino acid identity. The third subcluster, group C, consists of the structurally less related hair keratins KRTHA2, KRTHA5, and KRTHA6, which share about 70% amino acid identity.