Keratin Associated Protein 1-5 (KRTAP1-5)

KAP1.5; High sulfur keratin-associated protein 1.5

Keratin Associated Protein 1-5 (KRTAP1-5)
KRTAP1-5 is a member of the keratin-associated protein (KAP) family. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21.The deduced 174-amino acid protein has a calculated molecular mass of 18.0 kD.
KAP1.5 is classified as a high sulfur protein owing to a cysteine content of 24.1 mol %. It contains 2 unique motifs conserved among KAP1 family members, several characteristic pentapeptide repeats, and a 20-amino acid subdomain that was conserved among KAP1 family members in all species examined. In situ hybridization to cryosections of human scalp epidermis showed expression of KAP1.5 in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.

Organism species: Homo sapiens (Human)