Keratinocyte Proline Rich Protein (KPRP)

KPRP, The deduced 579-amino acid protein has a calculated molecular mass of 64 kD. It has a glutamine-rich N-terminal half, a proline-rich C-terminal half, and 8 putative N-myristoylation sites.

Northern blot analysis of mouse tissues detected Kprp expression in stomach and skin. In situ hybridization revealed KPRP expression in the upper granular layer of differentiated normal human skin. In human fetal skin, KPRP expression began in the periderm at 16 weeks' estimated gestational age (EGA), and it was expressed in the granular and horny layers of the epidermis at 24 weeks' EGA and thereafter. In mice, expression began at embryonic day 17.5. Western blot analysis detected KPRP at an apparent molecular mass of 70 kD.