Kindlin 1 (KIND1)

KIND1 colocalizes with vinculin and is therefore a component of focal contacts, which are structures involved in membrane-substratum attachment in cultured cells. They also found that KIND1 can associate to some extent with filamentous actin.The deduced 677-amino acid URP1 protein has a calculated molecular mass of 77.4 kD. In its C-terminal half, URP1 contains 2 FERM domains flanking a pleckstrin homology (PH) domain. URP1 shares 65.5% identity with MIG2 and 58.7% identity with URP2 . All 3 proteins share weak but significant homology with talin-1 and talin-2. Northern blot analysis detected strong expression of a 4.4-kb URP1 transcript in brain and skeletal muscle, weaker expression in kidney and placenta, and little to no expression in other tissues.