Kindlin 2 (KIND2)

FERMT2 is a component of extracellular matrix structures in mammalian cells and is required for proper control of cell shape change.MIG2 is transcribed from the opposite strand of the gene encoding transcription factor HTF4.The MIG2 protein shares significant homology with C. elegans Unc112, a novel FERM domain-containing protein that is essential for the assembly of integrin-containing muscle attachment structures.

migfilin interacts with MIG2 and the actin-binding protein filamin through its C- and N-terminal domains, respectively. Loss of MIG2 or migfilin impaired cell shape modulation. The authors determined that MIG2 recruits migfilin to cell-ECM adhesions, while the migfilin-filamin interaction mediates the association of migfilin with actin filaments.