Kringle Containing Transmembrane Protein 2 (KREMEN2)

The Krm2 protein contains an N-terminal signal sequence, followed by a kringle domain, a WSC domain, a CUB domain, a transmembrane domain, and an intracellular C-terminal tail.This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling.

The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.