Kruppel Like Factor 14 (KLF14)

KLF14 is a member of the Kruppel-like family of transcription factors. The gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. Expression of this gene is induced by TGF-beta, and the protein represses TGF-beta receptor II expression. The protein functions as part of a transcriptional co-repressor complex that also contains the transcriptional regulator SIN3A and histone deacetylase 2.KLF14 was expressed at low levels in many mouse and human tissues, with higher expression in fetal tissues and placenta than in adult tissues. It was not expressed in liver or lymphoblasts. KLF14 was monoallelically expressed from the maternal chromosome in all mouse and human embryonic tissues examined, but imprinting was not associated with the expected molecular signatures.