Kv Channel Interacting Protein 2 (KCNIP2)

KCNIP2 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The KCHIP2 cDNA encodes a 252-amino acid protein that has a distinct amino terminus but shares approximately 70% amino acid identity with KCHIP1 and KCHIP3 throughout a carboxy-terminal 185-amino acid core domain containing 4 EF-hand-like motifs.