LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2)

LIMS2 is a focal adhesion protein that associates with integrin-linked kinase (ILK), a multidomain protein that mediates multiple protein-protein interactions at adhesion sites between cells and the extracellular matrix (ECM).

LIMS2 forms a complex with ILK and that the interaction requires the first LIM domain (LIM1) of LIMS2. A LIM1-deletion mutant, unlike wildtype LIMS2, was incapable of localizing to cell-ECM contact sites, suggesting that ILK binding is required for this association. LIMS2-ILK and LIMS1-ILK interactions are mutually exclusive. Overexpression of LIMS2 in a mouse myoblast cell line inhibited the interaction between LIMS1 and ILK and reduced cell spreading and migration in rat embryo fibroblasts.LIMS2 shares 82% amino acid identity with LIMS1.