Lipoma Preferred Partner (LPP)

LPP a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease related chromosomal translocations which result in the expression of chimeric proteins that may promote tumor growth. Alternate splicing results in multiple transcript variants.The 612-amino acid open reading frame of LPP showed approximately 85% similarity to zyxin of chicken. Zyxinis a member of the LIM protein family whose members all possess LIM domains.