LIM Domains Containing Protein 1 (LIMD1)

LIM domains consist of a cysteine-rich consensus sequence containing 2 distinct zinc-binding subdomains, which mediate protein-protein interactions. The predicted protein sequences of the human and mouse genes show 3 LIM domains located at the C-terminal end, indicating that these genes belong to group 3 of the gene family encoding the LIM motifs. The predicted human LIMD1 protein contains 676 amino acids.

The LIM motif had been previously identified in many developmentally important factors from various eukaryotes. These factors had been shown to play a role in intracellular signaling, transcriptional regulation, and cellular differentiation during development. Thus, the C3CER1-located LIMD1 gene deserves further study for its possible role in tumor suppression.