Leptin Receptor Overlapping Transcript Like 1 (LEPROTL1)

The deduced 131-amino acid integral membrane protein has an external N terminus, an internal C terminus, and 3 transmembrane domains. It also contains a potential JAK2 phosphorylation site. LEPROTL1 shares 67% identity with a leptin receptor gene-related protein (OBRGRP, or LEPROT). Northern blot analysis revealed expression of a 2.9-kb main transcript in almost all tissues examined. Highest expression was detected in heart, testis, adrenal gland, thymus, and spleen, and lowest expression was detected in lung and skeletal muscle. Several transcripts were detected in some tissues, notably testis.Transgenic mice expressing both LEPROT and LEPROTL1 showed a more severe phenotype and significantly reduced expression of GH-dependent genes.