Leucine Rich Repeat Containing Protein 10 (LRRC10)

The deduced 274-amino acid protein has a predicted molecular mass of 31.2 kD and contains 7 leucine-rich repeats of 20 to 23 amino acids and 2 possible C-terminal nuclear localization signals. Northern blot analysis detected a 1.3-kb mouse Lrrc10 transcript exclusively in heart.

PCR analysis confirmed Lrrc10 expression in mouse heart with lower expression detected in skeletal muscle but not in any other tissues examined. In vitro transcription/translation of mouse Lrrc10 produced a peptide of approximately 35 kD. Confocal and fluorescence microscopy localized transfected Lrrc10 to the nucleus and mitochondria of COS-7 cells.