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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
Leucine Rich Repeat Kinase 1 (LRRK1)
RIPK6; Roco1
LRRK1 has a domain organization similar to that of LRRK2, with 6 N-terminal ankyrin repeats, followed by 14 leucine-rich repeats, a RAS (see HRAS)-like GTPase domain (ROC domain), a C-terminal to ROC (COR) domain, a serine/threonine kinase domain, and 7 C-terminal WD40 repeats. Highest expression of LRRK1 was in testis, placenta, prostate, and muscle, with moderate expression in brain, pancreas, small intestine, stomach, and spleen. LRRK1 underwent intramolecular, but not intermolecular, autophosphorylation. Replacement of lys1269 with trp in the ATP-binding niche of the kinase domain of LRRK1 significantly reduced autophosphorylation activity. LRRK1 also functioned as a GDP/GTP-binding protein, and its kinase activity was stimulated upon binding of GTP to the ROC domain.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME
Proteins RPH717Hu01 Recombinant Leucine Rich Repeat Kinase 1 (LRRK1) Customize
Antibodies PAH717Hu01 Polyclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1) Customize
MAH717Hu21 Monoclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1) Customize
Assay Kits SEH717Hu ELISA Kit for Leucine Rich Repeat Kinase 1 (LRRK1) Customize
SCH717Hu CLIA Kit for Leucine Rich Repeat Kinase 1 (LRRK1) Customize
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPH717Mu01 Recombinant Leucine Rich Repeat Kinase 1 (LRRK1) Customize
Antibodies PAH717Mu01 Polyclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1) Customize
MAH717Mu21 Monoclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1) Customize
Assay Kits SEH717Mu ELISA Kit for Leucine Rich Repeat Kinase 1 (LRRK1) Customize
SCH717Mu CLIA Kit for Leucine Rich Repeat Kinase 1 (LRRK1) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPH717Ra01 Recombinant Leucine Rich Repeat Kinase 1 (LRRK1) Customize
Antibodies PAH717Ra01 Polyclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1) Customize
MAH717Ra21 Monoclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1) Customize
Assay Kits SEH717Ra ELISA Kit for Leucine Rich Repeat Kinase 1 (LRRK1) Customize
SCH717Ra CLIA Kit for Leucine Rich Repeat Kinase 1 (LRRK1) Customize