Leucine Rich Repeat Kinase 1 (LRRK1)

RIPK6; Roco1; Leucine-rich repeat serine/threonine-protein kinase 1
Leucine Rich Repeat Kinase 1 (LRRK1)
LRRK1 has a domain organization similar to that of LRRK2, with 6 N-terminal ankyrin repeats, followed by 14 leucine-rich repeats, a RAS (see HRAS)-like GTPase domain (ROC domain), a C-terminal to ROC (COR) domain, a serine/threonine kinase domain, and 7 C-terminal WD40 repeats. Highest expression of LRRK1 was in testis, placenta, prostate, and muscle, with moderate expression in brain, pancreas, small intestine, stomach, and spleen. LRRK1 underwent intramolecular, but not intermolecular, autophosphorylation. Replacement of lys1269 with trp in the ATP-binding niche of the kinase domain of LRRK1 significantly reduced autophosphorylation activity. LRRK1 also functioned as a GDP/GTP-binding protein, and its kinase activity was stimulated upon binding of GTP to the ROC domain.
Organism species: Homo sapiens (Human)
  • Protein RPH717Hu01Recombinant Leucine Rich Repeat Kinase 1 (LRRK1)Customize
  • AntibodyPAH717Hu01Polyclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1)Customize
  • AntibodyMAH717Hu21Monoclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1)Customize
  • Assay KitSEH717HuELISA Kit for Leucine Rich Repeat Kinase 1 (LRRK1)Customize
  • Assay KitSCH717HuCLIA Kit for Leucine Rich Repeat Kinase 1 (LRRK1)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPH717Mu01Recombinant Leucine Rich Repeat Kinase 1 (LRRK1)Customize
  • AntibodyPAH717Mu01Polyclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1)Customize
  • AntibodyMAH717Mu21Monoclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1)Customize
  • Assay KitSEH717MuELISA Kit for Leucine Rich Repeat Kinase 1 (LRRK1)Customize
  • Assay KitSCH717MuCLIA Kit for Leucine Rich Repeat Kinase 1 (LRRK1)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPH717Ra01Recombinant Leucine Rich Repeat Kinase 1 (LRRK1)Customize
  • AntibodyPAH717Ra01Polyclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1)Customize
  • AntibodyMAH717Ra21Monoclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1)Customize
  • Assay KitSEH717RaELISA Kit for Leucine Rich Repeat Kinase 1 (LRRK1)Customize
  • Assay KitSCH717RaCLIA Kit for Leucine Rich Repeat Kinase 1 (LRRK1)Customize
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