Leucine Rich Repeat Kinase 2 (LRRK2)
AURA17; PARK8; RIPK7; ROCO2; Dardarin ; Parkinson Disease(Autosomal Dominant)8; Leucine-rich repeat serine/threonine-protein kinase 2
LRRK2 encodes a protein with an ankyrin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, an MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.LRRK2 interacts with the C-terminal R2 RING finger domain of parkin, and parkin interacted with the COR domain of LRRK2. Expression of mutant LRRK2 induced apoptotic cell death in neuroblastoma cells and in mouse cortical neurons. Mutations in this gene have been associated with Parkinson's disease type 8.Four LRRK2 gene variants found are found in a third of Parkinson’s cases, but infrequent in the general population.
Organism species: Homo sapiens (Human)
- Recombinant protein RPH716Hu01 Recombinant Leucine Rich Repeat Kinase 2 (LRRK2) In Stock
- Recombinant protein RPH716Hu02 Recombinant Leucine Rich Repeat Kinase 2 (LRRK2) In Stock
- Polyclonal antibody PAH716Hu01 Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) In Stock
- Polyclonal antibody PAH716Hu02 Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) In Stock
- Labelled antibody LAH716Hu71 Biotin-Linked Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) In Stock
- Sandwich ELISA SEH716Hu ELISA Kit for Leucine Rich Repeat Kinase 2 (LRRK2) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPH716Mu01 Recombinant Leucine Rich Repeat Kinase 2 (LRRK2) In Stock
- Polyclonal antibody PAH716Mu01 Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) In Stock
- Customized Service n/a CLIA Kit for Leucine Rich Repeat Kinase 2 (LRRK2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Leucine Rich Repeat Kinase 2 (LRRK2) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPH716Ra01 Recombinant Leucine Rich Repeat Kinase 2 (LRRK2) In Stock
- Monoclonal antibody MAH716Ra21 Monoclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) In Stock
- Polyclonal antibody PAH716Ra01 Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) In Stock
- Sandwich ELISA SEH716Ra ELISA Kit for Leucine Rich Repeat Kinase 2 (LRRK2) In Stock