Leucine Rich Repeat LGI Family, Member 2 (LGI2)

Lgi2 was expressed at low levels in most brain regions with high levels in the pyriform cortex and thalamic reticular nucleus. Lgi2 was secreted in transfected 293T cells. Immunofluorescence microscopy localized Lgi2 to discrete intracellular compartments, consistent with its presence in ER, Golgi bodies, and vesicles.

The deduced 542-amino acid protein shares 58% identity with LGI1. RT-PCR ELISA detected highest expression of LGI2 in heart, lung, kidney, and ovary, intermediate expression in liver and pancreas, low expression in brain and spleen, and little to no expression in skeletal muscle, testis, and spinal cord. Intermediate expression was detected in most specific brain regions examin