Leucine Rich Repeat Transmembrane Neuronal 4 (LRRTM4)

The deduced 518-amino acid protein contains an N-terminal signal sequence, followed by 10 extracellular LRRs flanked by cysteine-rich domains, a transmembrane region, and an intracellular tail. LRRTM4 has 4 N-glycosylation sites, several putative phosphorylation sites, and a C terminus that ends in the sequence ECEV, which is a characteristic of LRRTM family members. RT-PCR analysis detected prominent LRRTM4 expression in human CNS, including cerebellum, amygdala, caudate nucleus, corpus callosum, hippocampus, thalamus, and spinal cord, and intermediate levels in human lung, muscle, prostate, salivary gland, small intestine, stomach, and testis. In developing mice, Lrrtm4 expression began at embryonic day 15, and highest levels were reached at postnatal day 1 and persisted into adulthood.