Leucine Zipper Protein 5 (LUZP5)

Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 and SMC4 , but they contain different sets of non-SMC subunits. NCAPG2 is 1 of 3 non-SMC subunits that define condensin II .the condensin II-specific subunits CAPH2 (NCAPH2), CAPD3 (NCAPD3), and CAPG2 comigrated at about 13.5S. Immunofluorescence analysis of HeLa cells with anti-CAPG2 antibodies showed that condensins I and II had different distributions along metaphase chromosomes. Depletion of CAPG2 from HeLa cells or Xenopus egg extracts altered the shape of mitotic chromosomes, implying that CAPG2 has a role in maintaining the physical rigidity of the chromatid axis.