Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 6 (LILRA6)

LILRA6 belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.Receptors with a shorttail, CD85b (ILT8), CD85f (ILT11), CD85g (ILT7), CD85h (ILT1/LIR7) and CD85i (LIR6a) lack ITIMs and contain a positively charged aa residue, arginine or lysine, in their transmembrane domain which is necessary for association with ITIM-containing polypeptides like FcRg chain.

CD85b is expressed on NK and T cell subsets, monocytes, macrophages, dendritic cells and B lymphocytes. CD85b is a single-pass type-1 glycoprotein. It contains an extracellular domain, a transmembrane domain and a short cytoplasmic tail which lacks ITIMs. CD85b is involved in the activation of NK-mediated cytotoxicity and binds theFcRγchain.