Leukocyte Receptor Cluster Member 1 (LENG1)

LENG1 belongs to the leukocyte receptor cluster (LRC) present on 19q13.4. The chromosomal region 19q13.4 harbors the human leukocyte receptor cluster (LRC) which has been demonstrated to contain 19 genes encoding leukocyte-expressed receptors of the immunoglobulin (Ig) superfamily. A spotted PAC library was used to construct a contig of 65 overlapping clones spanning the complete LRC. The two ILT clusters are transcribed in opposite directions and are separated by about 200 kb, which contains two LAIR genes. The data suggest that the two ILT clusters, each including one LAIR locus, arose from a single ancestral ILT/LAIR cluster by inverse duplication of a c large genomic fragment. Furthermore, the NK cell-expressed NKp46 gene was localized 20 kb telomeric of FCAR; and 14 novel genes mapping within the LRC were identified by cDNA selection.