Ly6/PLAUR Domain Containing Protein 2 (LYPD2)

There are no apparent interactions between the SNP and the nearby GML promoter, despite its relative proximity (12 kb) in comparison to the LY6D (35 kb) and LYPD2 (70 kb) genes.LY6D and LYPD2 on the basis of chromatin conformation capture analysis, SLURP1 based on its unique status of secreted protein, and GML because of the proximity to the genetic marker. In general, all eight genes of the LY6/uPAR family show detectable, but very low levels of expression as assessed by quantitative RT-PCR.

LY6D and LYPD2, which showed relatively higher expression levels, were silenced in HeLa cells by small interfering RNA (siRNA). Silencing with three different siRNA was successful for LY6D and suboptimal for LY6PD2.