Lymphocyte Antigen 6H (LY6H)

The LY6 antigens are a family of glycosylphosphatidylinositol-anchored cell surface glycoproteins. Horie et al. (1998) identified LY6H, a novel member of the LY6 family, among random sequences from a human fetal brain cDNA library. The full-length cDNA encodes a 161-amino acid polypeptide which is 23 to 33% identical to other known family members. Northern blot analysis revealed that a 1-kb LY6H transcript was expressed at a high level in brain and at a lower level in testis, small intestine, and colon.

Horie et al. (1998) used FISH to map LY6H to human chromosome 8q24.3, a localization that is shared with other LY6 family members including LY6D , LY6E, and GML.