Lysine Specific Demethylase 4B (KDM4B)

The transcript contains an Alu element in its 3-prime UTR, and the deduced 819-amino acid protein shares weak identity with peregrin (BRPF2) over 432 amino acids. RT-PCR analysis detected high JMJD2B expression in all tissues examined.

By searching for sequences similar to JMJD1C, Katoh and Katoh (2004) identified several JMJD2 family genes, including JMJD2B. JMJD2B encodes a deduced 1,096-amino acid protein. Like JMJD2A and JMJD2C , JMJD2B contains a JmjN domain, a JmjC domain, a JD2H domain, 2 TUDOR domains, and a bipartite nuclear localization signal that overlaps the C-terminal part of the second TUDOR domain. JmjN is a small domain found in the Jumonji family of transcription factors. JmjC is a putative enzymatic domain. JD2H is a region containing 2 cys-his clusters with weak similarity to a PHD domain.