Lysocardiolipin Acyltransferase 1 (LCLAT1)

AGPAT1 is also called LPAATα, and AGPAT8 is also known as AGPAT9, LPAATθ, or GPAT3. Confusingly, LCLAT1 was also given the name AGPAT8. Human LPGAT1 overexpressed in COS-7 cells showed a clear preference for 16:0-, 18:0-, and 18:1-CoAs as donors, which is consistent with the composition of endogenous PG in several tissues. Human LPGAT1 is widely distributed in tissues. The enzyme has the KKXX motif and is localized to the ER.

Mouse LCLAT1 is widely distributed, with the highest expression seen in the heart and liver. When LCLAT1 was overexpressed in COS-7 cells, the enzyme localized to the ER. The subcellular localization was predicted by the existence of a KKXX motif, an ER retention signal at the C-terminal end of LCLAT1.