Lysozyme Like Protein 6 (LYZL6)

Lysozymes, especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL6 is a member of a family of lysozyme-like genes.

By EST database analysis using LYZ as query, followed by screening a human testis cDNA library, Zhang et al. (2005) cloned LYZL6. The deduced 148-amino acid protein shares 44% amino acid identity with LYZ and has 8 conserved cysteine residues found in all C-type lysozymes, a signal peptide sequence, and both catalytic glu35 and asp52 residues. family. Northern blot analysis of human tissues detected an approximately 1.0-kb transcript specifically in testis/epididymis.