MAP7 Domain Containing Protein 1 (MAP7D1)

MAP7D1 Belongs to the MAP7 family.MAP7 Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. Belongs to the MAP7 family. Up-regulated upon terminal differentiation of primary keratinocytes. Interacts with TRPV4. 3 isoforms of the human protein are produced by alternative splicing.Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas.