MAS Related GPR Member B (MRGPRB)

Many Mrgpr genes are clustered together on mouse chromosome 7. The deleted 845-kilobase region comprises ~30 Mrgpr genes, twelve of which (MrgprA1-4, A10, A12, A14, A16, A19, B4, B5 and C11) have intact open reading frames (ORFs). No other ORF is present in this region according to the Mouse Genome Project.

Although the mouse Mrgpr superfamily consists of over 50 members, more than half are pseudogenes and only ~24 genes have intact ORFs. Therefore, the deleted cluster represents ~50% of the potentially functional Mrgpr repertoire and contains most MrgprA and MrgprC genes as well as some members of the MrgprB subfamily.