MCF2 Cell Line Derived Transforming Sequence Like Protein 2 (MCF2L2)

ARHGEF22; DRG; Dbs-related Rho family guanine nucleotide exchange factor; Probable guanine nucleotide exchange factor MCF2L2

MCF2 Cell Line Derived Transforming Sequence Like Protein 2 (MCF2L2)
MCF2L2, ADIPOQ and SOX2 genes are located in chromosome 3q26-27, which is linked to diabetic nephropathy (DN). ADIPOQ and SOX2 genetic polymorphisms are found to be associated with DN.
Leu359Ile T/G variant in the MCF2L2 gene was found to be associated with DN in female subjects but not in males. The GG genotype carriers among female patients with DN had tendency decreased creatinine and cystatin levels compared to the carriers with either TT or TG genotypes. MCF2L2, ADIPOQ and SOX2 genetic polymorphisms have effects on the resistance of DN in female T1D patients, and suggests that the linkage with DN in chromosome 3q may be explained by the cumulated genetic effects.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)