MIND Kinetochore Complex Component Homolog (NSL1)

NSL1 encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene.MIS12 RNA interference (RNAi) abolished the kinetochore localization of DC8, C20ORF127, and ZWINT, and double RNAi against HP1-alpha and HP1-gamma (CBX3) abolished the kinetochore localization of MIS12 and DC8.