Magnesium Transporter 1 (MAGT1)

MAGT1 encodes a magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause mental retardation X-linked type 95 (MRX95). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29.The deduced 335-amino acid human protein has a calculated molecular mass of 38 kD. MAGT1 contains 5 putative transmembrane domains, the first of which is likely cleaved. It has an N-glycosylation site in its first extracellular loop and several putative phosphorylation sites in its N-terminal region. Northern blot analysis detected variable Magt1 expression in all mouse tissues examined. .