Major Facilitator Superfamily Domain Containing Protein 6 (MFSD6)

MMR2 orthologs were present in numerous species, and human MMR2 shares 98% and 84% amino acid identity with chimpanzee and mouse Mmr2, respectively. PCR analysis detected MMR2 in all 20 human tissues examined. In mouse tissues, strong expression was detected in brain, with weaker expression in 7 other tissues, prior to perfusion. After perfusion, strong expression was only present in brain, suggesting that Mmr2 is expressed in mouse brain and peripheral blood cells.

Variable levels of MMR2 expression were detected in peripheral blood mononuclear cells from healthy volunteers, including some showing no MMR2 expression. Expression of Mmr2 in peripheral blood cells also varied between mouse strains.