Makorin Ring Finger Protein 2 (MKRN2)

Members of the makorin family, including MKRN2, have a characteristic zinc finger composition that suggests that they are ribonucleoproteins.

The deduced 416-amino acid protein has a calculated molecular mass of 47.0 kD. MKRN2 contains 3 N-terminal C3H zinc fingers, a central typical makorin cys-his motif, a RING zinc finger motif, and a C-terminal C3H zinc finger.The longer transcript, which they designated MKRN2-FAR, extends 101 nucleotides into the 3-prime UTR of the oppositely oriented RAF1 gene and includes the complement of the tandem RAF1 polyadenylation signals. The shorter transcript, designated MKRN2-NEAR, has no region of overlap with RAF1.