Malate Dehydrogenase 2 (MDH2)

In both leukocytes and placentas, Davidson and Cortner (1967) found polymorphism of the malate dehydrogenase that is bound to mitochondria, called M-MDH originally and now symbolized MDH2. The fact that mitochondrial malate dehydrogenase was indistinguishable from normal in persons with variation in the supernatant MDH indicates that a separate locus is involved in its genetic determination. Mendelian segregation rather than maternal inheritance of MDH2 suggests that not all mitochondrial proteins are coded by mitochondrial DNA. Mitochondrial glutamic oxaloacetic transaminase is also determined by nuclear genes. From study of hybrid cells, Van Heyningen et al. (1975) mapped the locus for MDH2 to chromosome 7. Habets et al. (1992) subsequently mapped the locus to 7cen-q22.