Mannosidase Alpha Class 2A Member 1 (MAN2A1)

MAN2A1 is a member of family 38 of the glycosyl hydrolases. Alpha-mannosidase II (EC 3.2.1.114) is a Golgi enzyme that catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway, acting as the committed step in the conversion of high mannose to complex type structures.

Endoplasmic reticulum (ER) and Golgi alpha-mannosidases are involved in processing of newly synthesized N-glycans. Cytoplasmic alpha-mannosidases may be involved in degradation of dolichol intermediates that are not needed for protein glycosylation or oligosaccharides derived from glycoprotein turnover in the ER. Alpha-mannosidase II is a type II membrane protein residing mainly in the medial Golgi cisternae.