Mannosidase Alpha Class 2C Member 1 (MAN2C1)

Cytoplasmic alpha-mannosidase (MANA) was assigned to 15q11-qter by study of an X;15 translocation in man-mouse hybrids. Lysosomal alpha-mannosidase (MANB) has been assigned to chromosome 19 by somatic cell hybridization .

Neri et al. (1983) described a boy with a ring chromosome 15 derived from a t(15q;15q) chromosome of the mother. The ring chromosome was duplicated for a portion of the long arms near the centromere, probably cen-q13. Dosage effects suggested that the alpha-mannosidase gene is located in this segment. Since a shortest region of overlap (SRO) of 15q11-qter had been estimated by Ferguson-Smith and Westerveld (1979), the new information places the MAN2C1 gene in the 15q11-q13 segment.