Mast Cell Immunoreceptor Signal Transducer (MIST)

MIST is a member of the SLP76 family of adaptors . MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 -mediated mast cell degranulation .

The deduced 435-amino acid mouse protein contains a basic domain, a tyrosine- and proline-rich region, and an SH2 domain that shares 40 to 53% amino acid identity with the SH2 domains of SLP76 (LCP2) and Blnk . RNase protection assay detected low or undetectable Clnk expression in most mouse tissues, including bone marrow, lymph node, spleen, thymus, kidney, and hematopoetic cell lines.