Mediator Complex Subunit 19 (MED19)

MED19 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II.By searching a human brain cDNA library for clones containing a CAG repeat, Reddy et al. (1997) identified MED19, which they called DT2P1G7. Northern blot analysis detected a 1.3-kb MED19 transcript.Sato et al. (2003) purified several components of the human Mediator complex, including MED19, which they called LCMR1, and subsequently cloned the corresponding cDNA.Sato et al. (2003) found MED19 directly interacted with Mediator subunits SOH1 (MED31), TRAP80 (MED17), and TRAP37 (MED27). Interaction between MED19 and SOH1 was confirmed by coimmunoprecipitation analysis of transfected 293T cells and insect cells.