Mediator Complex Subunit 7 (MED7)

CRSP9; CRSP33; MED7; Cofactor Required For Sp1 Transcriptional Activation 9, 33kDa; Activator-recruited cofactor 34 kDa; Cofactor required for Sp1 transcriptional activation 9

Mediator Complex Subunit 7 (MED7)
Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene. The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus.
MED7 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. CRSP behaves as a single complex of approximately 700 kD.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)