Mediator Of Cell Motility 1 (MEMO1)

One of the precipitated proteins, identified by mass spectrometry, was a 33-kD product of a novel gene, which the authors named MEMO (mediator of ERBB2-driven cell motility). The predicted protein contains 297 amino acids. MEMO does not contain a predicted SH2- or PTB-phosphotyrosine-binding domain and suggested it may interact with ERBB2 through SHC. A MEMO-specific siRNA was shown to markedly reduce cell motility.

Unlike MEMO proteins in other species, however, there was no evidence for metal binding in the human protein. human MEMO directly binds to the ERBB2 phosphopeptide using a vestigial (dioxygenase) enzymatic active site.