Serpin Peptidase Inhibitor Clade B Member 7 (SERPINB7)
Megsin; TP55
The mice developed progressive mesangial matrix expression, an increase in the number of mesangial cells, and an augmented immune complex deposition, together with immunoglobulins and complement. Binding and functional assays in vitro identified plasmin as a biologic substrate of megsin and confirmed the activity of megsin as a proteinase inhibitor. Transgenic mice exhibiting nephritis as a result of treatment with antiglomerular basement membrane antiserum showed significantly more persistent expansion of the mesangial extracellular matrix than was seen in control mice. The amino acid sequences in the reactive loop site of megsin showed characteristic features of functional serpins. analyses of various tissues and cells demonstrated that megsin is predominantly expressed in human mesangial cells.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a Monoclonal Antibody to Serpin Peptidase Inhibitor Clade B Member 7 (SERPINB7) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Serpin Peptidase Inhibitor Clade B Member 7 (SERPINB7) Polyclonal Antibody Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
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- Customized Service n/a Monoclonal Antibody to Serpin Peptidase Inhibitor Clade B Member 7 (SERPINB7) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Serpin Peptidase Inhibitor Clade B Member 7 (SERPINB7) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Serpin Peptidase Inhibitor Clade B Member 7 (SERPINB7) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Serpin Peptidase Inhibitor Clade B Member 7 (SERPINB7) ELISA Kit Customized Service Offer