Membrane Protein, Palmitoylated 7 (MPP7)

Membrane-associated guanylate kinases (MAGUKs) are important adaptor proteins involved in the assembly of protein complexes at sites of cell-cell contact.

MPP7 belongs to the p55 stardust subfamily of MAGUKs, which is named for a Drosophila gene required for establishment of cell polarity in the developing fly embryo.The deduced 576-amino acid protein has 2 L27 domains (L27N and L27C) at its N terminus, followed by a PDZ domain, an SH3 domain, and a C-terminal GUK domain. It shares 93% amino acid identity with mouse Mpp7, 76% identity with the zebrafish humpback protein, and 56% identity with human MPP3. In silico expression analysis suggested that MPP7 is widely expressed.