Membrane Spanning 4 Domains Subfamily A, Member 6A (MS4A6A)

MS4A6A encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants.The deduced 178-amino acid protein has 4 potential phosphorylation sites, including 1 at the intracellular loop, and a nonhydrophilic C terminus. Northern blot analysis revealed low-level expression of a 1.3-kb transcript in mouse kidney and small intestine and a 1.0-kb transcript in mouse heart; no expression was detected in human tissues.